And Mrs is a comedy drama about Gemma, a woman living in London whose American fiancé, Nathan, dies shortly before their wedding day. Never a true believer in modern marriage, Nathan's death makes Gemma re-evaluate the promise of a life spent together. When, with some encouragement from Nathan’s chaotic and unconventional sister, Audrey, she decides to go ahead with the wedding anyway, she has to overcome public opinion, the law of the land and even her own family’s objections for the right to finally say “I do”.