In 1889, Italian immigrant Francesca Cabrini arrives in New York City, greeted only by disease, crime, and impoverished children. Witnessing the vast inequality of the city, Cabrini sets off on a daring mission to help society’s most vulnerable, but must first overcome the prejudices and indifference of those in power. However, despite these momentous setbacks, her broken English, and poor health, she remains determined to use her entrepreneurial mind to build an empire of hope unlike anything that the world has ever seen.